Premature ovarian failure (POF), also known as premature ovarian insufficiency (POI), is a condition characterized by loss of normal ovarian function before the age of 40. It is considered premature menopause and affects approximately 1% of women under the age of 40.
There are several potential causes of POF:
| Cause | Description |
|---|---|
| Genetic factors | Chromosomal abnormalities and genetic mutations can disrupt normal ovarian function |
| Autoimmune disorders | When the body's immune system attacks the ovaries |
| Enzyme deficiencies | Enzymes needed for proper ovarian function are deficient |
| Radiation/chemotherapy | Cancer treatments that can damage the ovaries |
The main symptom of POF is irregular periods or amenorrhea (lack of periods) for at least 4 months. Other symptoms include:
Diagnosis of POF involves:
| Diagnostic Test | Description |
|---|---|
| Blood tests | FSH, estradiol, AMH levels |
| Pelvic exam | Visual exam of ovaries |
| Chromosome analysis | Check for chromosomal defects |
| Ovarian biopsy | Examine ovarian follicles |
Treatment focuses on relieving symptoms and preserving fertility if desired. Hormone replacement therapy with estrogen and progesterone can help alleviate symptoms. Infertility treatment may be an option. Eggs can be frozen to preserve fertility.
At Balance Clinic, we specialize in treating hormonal disorders like POF. Our experienced physicians provide comprehensive care including hormone therapy, fertility preservation, genetic counseling, and emotional support. We utilize state-of-the-art diagnostic testing and evidence-based treatment plans tailored to each patient's unique needs. Schedule a consultation today to discuss your options. We're here to help you through this challenging diagnosis.
In summary, premature ovarian failure is the early depletion of ovarian follicles before age 40. It causes infertility and menopausal symptoms. While there is no cure, symptoms can be managed through hormone therapy and fertility can sometimes be preserved. If you're experiencing irregular cycles or infertility, see your doctor to determine if POF could be the cause. With specialized care, women can still live full and rewarding lives despite POF. Let us help guide you on that journey.